TITLE
Tablet
Friability
OBJECTIVE
To determine the tablet friability using the friability tester at a
certain rate within a certain time.
INTRODUCTION
A
tablet’s durability may be determined through the use of a friabilator.
This apparatus determines the tablet’s friability, or tendency to crumble,
by allowing it to roll and fall within the drum. The tablets are weighed before
and after a specified number of rotations and any weight loss is determined.
Resistance to loss of weight indicates the tablet’s ability to withstand
abrasion in handling, packaging, and shipment. A maximum weight loss of not
more than 1% generally is considered acceptable for most products. Friability is
one of the non official tests. This
test is a method to determine physical strength of uncoated tablets upon
exposure to mechanical shock and attrition.
APPARATUS AND MATERIALS
 |
| Friability machine |
 |
| brush |
 |
| 10 tablets |
 |
| weighing boat |
EXPERIMENTAL METHOD
10
tablets were selected and weighed. All tablets were put into the drum of the
tablet abration and friability tester. The rate of rotation was set to 100 rpm,
time to 10 minutes and the operation was started. At the end of the operation,
remove all the tablets were removed and ensure it is
ensured that all the tablets were free from dust or powder by using the
brush. The tablets were then weighted again. The percentage loss of weight was
determined. Compressed tablet neither should nor lose more than 1% of its
weight.
RESULTS AND CALCULATIONS
Weight of tablet before
friability test = 6.5773g
Weight of tablet after
friability test = 6.5318g
Weight of tablet loss =
6.5773g – 6.5318g = 0.0455g
Percentage of tablet
loss: 0.05455g/6.5773x 100%= 0.6918%
DISCUSSION
Friability is defined
as the percentage of weight loss by tablets due to mechanical action during the
test. Tablets are weighed after and before the testing and the friability are
expressed as the percentage loss. Friability refers to the ability of the
compressed tablet to avoid fracture and breaking during transport. This
experiment is very important for the transportation of the pharmaceutical
product (tablet). An instrument called friabilator is used to evaluate the
ability of the tablet to withstand abrasion in packaging, handling and
shipping. According to the results, the weight loss of the tablets is not more
than 1%. This shows that the test of the friability of the tablet is passed.
CONCLUSION
The results are
accepted because the range of friability of the tablet is not more than 1%.
REFERENCES
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